منابع مشابه
Energetics of Shortening Muscles in Twitches and Tetanic Contractions
The extra heat liberation accompanying muscular shortening, the force-determined shortening heat, is defined as the difference between the heat produced when shortening occurs and that produced in an isometric contraction developing the same amount of force and performing the same amount of internal work. Based on this definition, the initial energy production in twitches and tetanic contractio...
متن کاملMultiscale measurement of cardiac energetics.
Herein we describe our laboratories' experimental methods for interrogating cardiac energetics at the organ (whole heart), tissue (trabecula) and perforated fibre (mitochondrial) levels. In whole heart and trabecula experiments, we focus on measuring pressure-volume (force-length) work and oxygen consumption (heat production) from which mechanical efficiency is derived. In both preparations (i....
متن کاملLife of mice – development of cardiac energetics
Production and transfer of metabolites like ATP and phosphocreatine within cardiomyocytes is crucial for the robust availability of mechanical work. In mammalian cardiomyocytes,mitochondria, themain suppliers of usable chemical energy in the form of ATP, are situated adjacent to both the ATPases near the mechanical apparatus, and the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) calcium pump...
متن کاملDomoic acid impairment of cardiac energetics.
Excitatory mediated neuronal injury has been shown to involve a complex cascade of events. However, the associated cardiac damage reported in humans and marine animals following exposure to excitotoxins has not been well characterized. We hypothesized that the excitotoxin domoic acid can traverse cardiac cell membranes and elicit a deleterious effect on cardiac mitochondrial energetics. Domoic ...
متن کاملEnergy Production in Cardiac Isotonic Contractions
The energy output of rabbit papillary muscle is examined and it is shown that there is more energy liberated in an afterloaded isotonic contraction than in an "equivalent" isometric contraction. This statement holds true regardless of whether equivalence is based on the proposition that tension or the time integral of tension is the best index of muscle energy expenditure. Besides the external ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1967
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1967.sp008235